Research

Tissue Repair Research Group

The members of the Tissue Repair Group, Drs. Sato-Bigbee, Diegelmann, Zehner, Beckmann, Spiegel, Fang, Barton, and Ratz, are studying how a variety of tissues respond to injury. Among these are smooth and cardiac muscle, bone, and brain tissues. The members of this group have expertise in signal transduction, the regulation of gene expression, and the biology of the extracellular matrix. The studies of this group are intended to better understand the endogenous healing processes of the body in hopes that these can be harnessed to promote more efficient and substantial wound healing in clinical settings.

Robert Diegelmann  Robert Diegelmann, Professor: Regulation of collagen deposition following tissue injury.
Carmen Sato-Bigbee  Carmen Sato-Bigbee, Associate Professor

Regulatory pathways and mechanisms of gene regulation during brain development and regeneration, molecular mechanisms involved in oligodendrocyte development and myelination.
Paul Ratz  Paul Ratz, Professor:

Regulation of contraction of vascular and bladder smooth muscles.
Zendra Zehner  Zendra Zehner, Professor:

R Regulation of gene expression in fibroblasts, macrophages and endothelial cells; Mechanisms of transcriptional repression; microRNAs involved in wound healing and inflammation
Sarah Spiegel  Sarah Spiegel, Professor:

Role of sphingosine-1-phosphate in tissue repair and smooth muscle cell contraction and migration.
Frank Fang  Frank Fang, Associate Professor:

The regulation of phospholipid synthesis, metabolism and signaling in acute and chronic wound healing.
William Barton  William Barton, Assistant Professor:

X-ray crystallography of extracellular receptor-ligand complexes and intracellular signaling pathways.
VCU Department of Physiology and Biophysics Virginia Commonwealth University VCU Medical Center
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