Research

Structural Biology Research Group

The members of the Structural Biology Group, Drs. Wright, Peterson, Bell, Barton, and Scarsdale, are using biophysical approaches to study the functioning and regulation of proteins, RNA-protein complexes, lipids, and lipoproteins. They are using X-ray crystallography, nuclear magnetic resonance (NMR), cryoelectronmicroscopy, calorimetry, and circular dichroism (CD) to uncover the molecular mechanisms that underlie atherosclerosis, viral hepatitis, Alzheimer’s disease, and other disorders.

Darrell Peterson  Darrell Peterson, Professor:

Structure and function of proteins of hepadnaviruses and hepatitis C virus.
Neel Scarsdale  J. Neel Scarsdale, Assistant Professor:

X-ray crystallography, protein engineering, protein folding and structures of serpins and their roles in Alzheimer’s disease
Tonie Wright  H. Tonie Wright, Professor:

X-ray crystallography, protein engineering, structures of serpins and their roles in alzheimer’s disease, enzymes of fatty acid biosynthesis, RNA-decapping protein.
William Barton  William Barton, Assistant Professor:

X-ray crystallography of extracellular receptor-ligand complexes and intracellular signaling pathways.
Jessica Bell  Jessica Bell, Assistant Professor:

SStructural and biochemical analysis of protein:protein interactions in the signaling cascade of pathogen recognition receptors.
VCU Department of Physiology and Biophysics Virginia Commonwealth University VCU Medical Center
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