Research

Neuroscience Research Group

The Neuroscience Group, Drs. Sato-Bigbee, Milstien, Scarsdale, Kordula, Chen, Dent, You and Wright, are using biochemical, molecular, and structural approaches to understand the pathogenesis of alzheimer’s disease and multiple sclerosis and to elucidate the molecular signaling events that are essential for the growth and differentiation of oligodendrocytes and neurons. Much of their work is focused on understanding how neuronal cells sense changes in their environment and the molecular events that allow them to make appropriate responses to these changes. It is hoped that a more detailed understanding of these responses will provide insights into novel treatments for neuronal diseases.

Carmen Sato-Bigbee Carmen Sato-Bigbee, Associate Professor:

Regulatory pathways and mechanisms of gene regulation during brain development and regeneration, molecular mechanisms involved in oligodendrocyte development and myelination.
Neel Scarsdale  J. Neel Scarsdale, Assistant Professor:

X-ray crystallography, protein engineering, protein folding and structures of serpins and their roles in Alzheimer’s disease.
Tony Wright  H. Tonie Wright, Professor:

X-ray crystallography, protein engineering, protein folding and structures of serpins and their roles in Alzheimer’s disease.
Sheldon Milstien  Sheldon Milstien, Professor:

Regulation of nitric oxide production in neuronal development.
Tomek Kordula  Tomek Kordula, Associate Professor:

Regulation of gene expression by proinflammatory cytokines in human astrocytes.
Jason Chen  Jason Chen, Associate Professor:

G-protein signaling in neurodevelopment and in neurodegenerative diseases.

Young You  Young You, Assistant Professor:

Genetics of appetite control in C. elegans.

Paul Dent  Paul Dent, Professor:

Cytolysis of human glioma tumors by ionizing radiation.

VCU Department of Physiology and Biophysics Virginia Commonwealth University VCU Medical Center
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