Research

Lipid signaling and metabolism

The members of the bioactive lipid signaling and metabolism group, Drs. Peterson, Gil, Dent, Barbour, Chalfant, Fang, Kordula, Baker, Larner, and Spiegel are using biochemical and molecular approaches to further understand metabolism and the functions of bioactive lipids in health and disease. New and unexpected biological functions, biosynthetic pathways and receptors are being revealed for lipids and metabolites as appreciation of their complex interactions with protein and DNA increases. Bioactive lipid mediators are now recognized to regulate a broad swath of biology from inflammation to allergy, immunity, cancer, cardiovascular and metabolic diseases, and more are being uncovered at an expanding rate. Expansion of our understanding of metabolism and the role of lipid mediators affords the opportunity for novel therapeutics

Darrell Peterson  Darrell Peterson, Professor:

Structure and function of proteins of hepadnaviruses and hepatitis C virus.
Gregorio Gil  Gregorio Gil, Associate Professor:

Molecular mechanisms of cholesterol and bile acid regulation of gene expression.
Suzanne Barbour  Suzanne Barbour, Professor:

Role of PLA2 and lipid mediators in the regulation of sterol metabolism.
Paul Dent  Paul Dent, Professor:

Signaling processes regulating survival of liver cells.

Charles Chalfant Charles Chalfant, Associate Professor:

Role of ceramide-1- phosphate in prostanoid synthesis.
Frank Fang Frank Fang, Associate Professor:

The role of phospholipids, particularly lysophosphatidic acid (LPA) in the pathogenesis of ovarian, breast, and prostate cancer.
Tomek Kordula Tomek Kordula, Associate Professor:

Role of inflammatory cytokines and growth factors in deregulation of proteolytic balance in human astrocytes.
Keith Baker Keith Baker, Associate Professor:

Understanding the physiological role of nuclear hormone receptors: mechanism of regulated transcription; metabolic homeostasis
Andrew Larner Andrew Larner, Professor:

Integration of Jak/ Stat signaling and cell growth pathways. The Role of the Jak/Stat Signaling Pathway in Regulation of Gene Expression and Cell Metabolism.
Sarah Spiegel Sarah Spiegel, Professor:

Role of sphingosine-1-phosphate in regulation of cell growth, apoptosis, and angiogenesis in human breast and prostate cancers.
VCU Department of Physiology and Biophysics Virginia Commonwealth University VCU Medical Center
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