Lipidomics, Proteomics and Genomics Research Group
The terms genomics, proteomics, and lipidomics refer to the systematic study of changes in gene expression, protein modification, and lipid mediators that occur in response to extracellular stimuli. Although most investigators in the Department of Biochemistry use these approaches in their research programs, the members of the Genomics/ Proteomics/ Lipidomics Group are at the forefront of the development and application of these technologies. These individuals, Drs. Spiegel, Sumitra Deb, Swati Deb, Beckman, Zehner, Kordula, Fang, Grogan, Roesser, Chen, and Milstien, are applying systems approaches to study important biological questions pertaining to cancer, heart disease, tissue repair and wound healing, and development.
Sarah Spiegel, Professor: |
Regulation of cell growth, motility, apoptosis, angiogenesis and cancer by sphingolipid metabolites.
Sheldon Milstien, Professor: |
Regulation of nitric oxide production, neuronal development, and apoptosis by sphingolipid metabolites.
Swati Deb, Associate Professor: |
Role of MDM2 and other oncogenes in cell growth regulation and deregulation using cell cycle analysis and proteomics.
Sumitra Deb, Professor: |
Microarray analysis of genes regulated by wild type versus mutant p53.
Tomek Kordula, Associate Professor: |
Tissue-specific expression of Serpin genes.
Charles Chalfant, Associate Professor: |
Role of macrophages in inflammation leading to atherogenesis, signaling pathways that mediate the release of eicosanoids and other proinflammatory/ pro-atherogenic lipid mediators.
Frank Fang, Associate Professor: |
Genetic overexpression or disruption of the LPA receptors in mice; malignancy-associated alterations in cellular lipid composition and functionality
James Roesser, Assistant Professor: |
RNA splicing, tissue-specific regulation of calcitonin/ CGRP mRNA splicing, role of alternative mRNA splicing in pathogensis of Neurofibromatosus type I
Jason Chen, Associate Professor:|
Impact of photoreceptor mutations on signal transduction in the visual system.
Understanding the physiological role of nuclear hormone receptors; mechanisms of regulated transcription; metabolic homeostasis.