Department Directory

H. Tony Wright, Ph.D.

Tony WrightProfessor of Biochemistry & Molecular Biology

PO Box 980614
Richmond, VA 23298-0614

Email: xrdproc@hsc.vcu.edu
Telephone: 804-828-6139

Education
  • AB, Princeton University, 1963
  • Ph.D., Chemistry,University of California, San Diego, 1968
Post-Doc
  • Postdoctoral Fellow, NIH, University of California, San Diego, 1968-1969
  • Postdoctoral Fellow, NIH, MRC Laboratory of Molecular Biology, Cambridge, England, 1969-1971
Research

Research Our broad objectives are to understand the interactions of biological macromolecules and enzymatic mechanisms at the atomic level and to correlate this information with cellular level phenomena. Our approaches utilize x-ray crystallography, recombinant DNA methods, molecular model building and in vitro physical and biochemical methods. We collaborate closely with other research groups that have complementary research approaches and mutual interests. In collaboration with Umesh Desai’s group in the Dept. of Medicinal Chemistry we are studying the interactions of synthetic polyanionic molecules with proteins of the thrombosis/fibrinolysis pathway as possible replacement anticoagulants for heparin. We are also collaborating with Dr. J. P. Lewis of the Dept. of Oral and Craniofacial Surgery in the Philips Institute of the School of Dentistry in structural studies of transcriptional regulators of oxidative stress response genes in bacteria. Finally, we are studying the interactions of the Alzheimer’s amyloid peptide Aβ in its different forms with inflammatory proteins and the effects of these interactions on reactive oxygen release from activated rat microglia, phenomena that are implicated in the etiology of Alzheimer’s disease.

Publications

View Dr. Wright's Publications via the National Library of Medicine's PubMed.

 

VCU Department of Biochemistry and Molecular Biology Virginia Commonwealth University VCU Medical Center
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