H. Tony Wright, Ph.D.Professor of Biochemistry & Molecular Biology
PO Box 980614
Richmond, VA 23298-0614
- AB, Princeton University, 1963
- Ph.D., Chemistry,University of California, San Diego, 1968
- Postdoctoral Fellow, NIH, University of California, San Diego, 1968-1969
- Postdoctoral Fellow, NIH, MRC Laboratory of Molecular Biology, Cambridge, England, 1969-1971
Research Our broad objectives are to understand the interactions of biological macromolecules and enzymatic mechanisms at the atomic level and to correlate this information with cellular level phenomena. Our approaches utilize x-ray crystallography, recombinant DNA methods, molecular model building and in vitro physical and biochemical methods. We collaborate closely with other research groups that have complementary research approaches and mutual interests. In collaboration with Umesh Desai’s group in the Dept. of Medicinal Chemistry we are studying the interactions of synthetic polyanionic molecules with proteins of the thrombosis/fibrinolysis pathway as possible replacement anticoagulants for heparin. We are also collaborating with Dr. J. P. Lewis of the Dept. of Oral and Craniofacial Surgery in the Philips Institute of the School of Dentistry in structural studies of transcriptional regulators of oxidative stress response genes in bacteria. Finally, we are studying the interactions of the Alzheimer’s amyloid peptide Aβ in its different forms with inflammatory proteins and the effects of these interactions on reactive oxygen release from activated rat microglia, phenomena that are implicated in the etiology of Alzheimer’s disease.